Mukhtar Singh

Graduate Student

Center for Free-Electron Laser Science (CFEL)
Deutsches Elektronen-Synchrotron DESY
Notkestrasse 85 (building 99, room O3.006)
22607 Hamburg
Germany

The Hamburg Centre for Ultrafast Imaging
Universität Hamburg
Luruper Chaussee 149
22761 Hamburg
Germany

Imaging chemical dynamics

mukhtar.singh@cfel.de

+49-40-8998-6341

Research

Laser induced electron diffraction of intrinsic reaction coordinates

Curriculum Vitae

since 2021	PhD student at the Center for Free Electron Laser Science, DESY, Hamburg
2018-2020	M.Sc. in Physics at the Indian Institute of Technology Hyderabad (IIT-H), India
2014-2017	B.Sc. (Honors) in Physics at the University of Delhi, India

Publications

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Next seminars

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Breakthrough in laser-alignment for macromolecular single-particle imaging

10 April 2025

Single-particle diffractive imaging (SPI) using X-ray free-electron lasers allows researchers to reconstruct the structure of nanoparticles and biomolecules. However, the technique often requires imaging up to several billion nanoparticles to produce the image and imposes limitations on its clarity and sharpness. Researchers at the Center for Free-Electron Laser Science at DESY, together with international colleagues, recently demonstrated that laser-induced alignment can indeed be achieved to significantly improve molecular imaging techniques. This geometric confinement of the molecules in the x-ray-imaging experiment will greatly facilitate the recovery of the molecular orientation and, therefore, the structure retrieval. It thus overcomes a significant challenge in single-particle diffractive imaging. This novel development further paves the way for solving the three-dimensional structures of proteins and other macromolecules using SPI.

Timepix3: single-pixel multi-hit energy-measurement behaviour

13 November 2024

The event-driven hybrid-pixel detector readout chip, Timepix3, has the ability to simultaneously measure the time of an event on the nanosecond timescale and the energy deposited in the sensor. However, the behaviour of the system when two events are recorded in quick succession of each other on the same pixel was not studied in detail previously. We present experimental measurements, circuit simulations, and an empirical model for the impact of a preceding event on this energy measurements, which can result in a loss as high as 70%. Accounting for this effect enables more precise compensation, particularly for phenomena like timewalk. This results in significant improvements in time resolution — in the best case, multiple tens of nanoseconds — when two events happen in rapid succession.

Recent Publications