Controlled Molecule Imaging

Unraveling the Structure‑Function Relationship in the Molecular Sciences

We develop innovative methods to obtain full control over large molecules and nanoparticles. These methods and the created controlled samples are exploited in fundamental physics and chemistry studies to unravel the underlying mechanisms of chemistry and biology by watching molecules at work.

Highlights

Thermal-energy-dynamics proposal paper selected as HOT PCCP article

09 January 2024

Our article "Unraveling the ultrafast dynamics of thermal-energy chemical reactions" by Matthew and Jochen was selected as 2023 HOT PCCP article by the editors of the journal Phys. Chem. Chem. Phys. of the Royal Society of Chemistry due to due to its strong readership feedback.

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Position in scientific management

03 January 2025

Timepix3: single-pixel multi-hit energy-measurement behaviour

13 November 2024

The event-driven hybrid-pixel detector readout chip, Timepix3, has the ability to simultaneously measure the time of an event on the nanosecond timescale and the energy deposited in the sensor. However, the behaviour of the system when two events are recorded in quick succession of each other on the same pixel was not studied in detail previously. We present experimental measurements, circuit simulations, and an empirical model for the impact of a preceding event on this energy measurements, which can result in a loss as high as 70%. Accounting for this effect enables more precise compensation, particularly for phenomena like timewalk. This results in significant improvements in time resolution — in the best case, multiple tens of nanoseconds — when two events happen in rapid succession.

Recent Publications

Journal Article Peravali, S. K. (Corresponding author)CFEL*Extern* ; Samanta, A. K.CFEL*XFEL.EU*DESY* ; Amin, M.CFEL*Extern* ; Neumann, P.Extern*DESY* ; Küpper, J.CFEL*XFEL.EU*DESY* ; Breuer, M. (Corresponding author)CFEL*
An improved numerical simulation methodology for nanoparticle injection through aerodynamic lens systems
Physics of fluids 37, 033380 (2025) [10.1063/5.0260295]2025 OpenAccess Files BibTeX | EndNote: XML, Text | RIS

Journal Article Ekeberg, T.CFEL*Extern*XFEL.EU* ; Assalauova, D.Extern*XFEL.EU*DESY* ; Bielecki, J.XFEL.EU* ; Boll, R.XFEL.EU* ; Daurer, B. J.Extern* ; Eichacker, L. A.Extern*XFEL.EU* ; Franken, L. E.CSSB* ; Galli, D. E.XFEL.EU* ; Gelisio, L.CFEL*XFEL.EU*DESY* ; Gumprecht, L.CFEL*XFEL.EU*DESY* ; Gunn, L. H.Extern*XFEL.EU* ; Hajdu, J.Extern* ; Hartmann, R.Extern* ; Hasse, D. ; Ignatenko, A.CFEL*XFEL.EU*DESY* ; Koliyadu, J.XFEL.EU*DESY* ; Kulyk, O.Extern* ; Kurta, R.XFEL.EU* ; Kuster, M.XFEL.EU* ; Lugmayr, W.CSSB* ; Lübke, J.CFEL*Extern*XFEL.EU* ; Mancuso, A. P.Extern*XFEL.EU* ; Mazza, T.XFEL.EU* ; Nettelblad, C.Extern*XFEL.EU* ; Ovcharenko, Y.XFEL.EU* ; Rivas, D. E.XFEL.EU* ; Rose, M.Extern*XFEL.EU* ; Samanta, A. K.CFEL*XFEL.EU*DESY* ; Schmidt, P.XFEL.EU* ; Sobolev, E.XFEL.EU*EMBL* ; Timneanu, N.Extern* ; Usenko, S.XFEL.EU* ; Westphal, D.Extern* ; Wollweber, T.Extern* ; Worbs, L.CFEL*XFEL.EU*DESY* ; Xavier, P. L. ; Yousef, H.XFEL.EU* ; Ayyer, K.CFEL*MPG*XFEL.EU* ; Chapman, H. N.CFEL*XFEL.EU*DESY* ; Sellberg, J. A.Extern*XFEL.EU* ; Seuring, C.CFEL*CSSB*XFEL.EU* ; Vartanyants, I. A.XFEL.EU*DESY* ; Küpper, J.CFEL*XFEL.EU*DESY* ; Meyer, M. ; Maia, F. R. N. C. (Corresponding author)Extern*XFEL.EU*
Observation of a single protein by ultrafast X-ray diffraction
Light 13(1), 15 (2024) [10.1038/s41377-023-01352-7]2024 OpenAccess Files BibTeX | EndNote: XML, Text | RIS

Journal Article He, L.CFEL*Extern*XFEL.EU* ; Johny, M.CFEL*Extern*XFEL.EU* ; Kierspel, T.CSSB*DESY* ; Dlugolecki, K.CFEL*XFEL.EU*DESY* ; Bari, S.DESY* ; Boll, R.XFEL.EU* ; Bromberger, H.CFEL*XFEL.EU*DESY* ; coreno, m.Extern*XFEL.EU* ; De Fanis, A.XFEL.EU* ; Di Fraia, M.Extern* ; Erk, B.XFEL.EU*DESY* ; Gisselbrecht, M.Extern* ; Grychtol, P.XFEL.EU* ; Eng-Johnsson, P.Extern*XFEL.EU* ; Mazza, T.XFEL.EU* ; Onvlee, J.CFEL*Extern*XFEL.EU* ; Ovcharenko, Y.XFEL.EU* ; Petrovic, J.Extern*XFEL.EU*DESY* ; Rennhack, N.XFEL.EU* ; Rivas, D.XFEL.EU* ; Rudenko, A.Extern* ; Ruehl, E.Extern* ; Schwob, L.XFEL.EU*DESY* ; Simon, M.Extern* ; Trinter, F.Extern*XFEL.EU* ; Usenko, S.XFEL.EU* ; Wiese, J.CFEL*Extern*XFEL.EU* ; Meyer, M.XFEL.EU* ; Trippel, S. (Corresponding author)CFEL*XFEL.EU*DESY* ; Küpper, J. (Corresponding author)CFEL*XFEL.EU*DESY*
Controlled molecule injector for cold, dense, and pure molecular beams at the European x-ray free-electron laser
Review of scientific instruments 95(11), 113301 (2024) [10.1063/5.0219086]2024 OpenAccess Files Fulltext BibTeX | EndNote: XML, Text | RIS

Controlled Molecule Imaging

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Unraveling the Structure‑Function Relationship in the Molecular Sciences

Highlights

Thermal-energy-dynamics proposal paper selected as HOT PCCP article