Freeze-and-deposit sample delivery for cryo-electron microscopy

Development of a novel, disruptive sample-preparation approach for cryo-electron microscopy

Impression of the prototype from the CMI lab.

We are developing a disruptive freeze-and-deposit sample preparation for cryo-electron microscopy. We are currently validating the technology concept in collaboration with scientific partners from the University Hospital Hamburg-Eppendorf (UKE) at the Center for Structural Systems Biology (CSSB), located on the DESY campus, and industry. The goal is to accelerate the transfer of this innovative and promising technique to a practical use-case ind structural-biology applications.

Research Team
Kevin Janson, Madeline Memovich, Amit Samanta, Jochen Küpper

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Timepix3: single-pixel multi-hit energy-measurement behaviour

13 November 2024

The event-driven hybrid-pixel detector readout chip, Timepix3, has the ability to simultaneously measure the time of an event on the nanosecond timescale and the energy deposited in the sensor. However, the behaviour of the system when two events are recorded in quick succession of each other on the same pixel was not studied in detail previously. We present experimental measurements, circuit simulations, and an empirical model for the impact of a preceding event on this energy measurements, which can result in a loss as high as 70%. Accounting for this effect enables more precise compensation, particularly for phenomena like timewalk. This results in significant improvements in time resolution — in the best case, multiple tens of nanoseconds — when two events happen in rapid succession.

Keynote lecture at Sino-German Physics Conference

20 October 2024

Jochen presented a keynote lecture on CMI research at the 33rd Annual Meeting of the Chinese Society of Physicists in Germany (GCPD) in Jinan, Shadong, China. The lecture was well attained locally and, according to the organizers, followed by more than 10,000 people in the koushare online stream.

Recent Publications